Potkani

ApoE rat
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Rat model Alzheimer's disease with ApoE knockout for a wide range of studies of type II diabetes, obesity, atherosclerosis, insulin resistance and hypertension.
APP Knockout Rat
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Rat model for Alzheimer's research, dementia and other neurodegenerative diseases.
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The model contains monoallelic deletion of the BDNF gene. Useful in the study of Alzheimer's, depression, pain, nerve growth, loss of memory.
bdnf rat alzheimers 4
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Knockout the gene encoding the ABC transporter, a critical in exporting pump bile salts.
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Knockout model encoding CAR having effects on induction of cytochrome p450s. It has applications in the study of hepatotoxicity, cholestasis and drug metabolism.
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Model with the lack of expression of the CFTR protein leads to cystic fibrosis and disruption of transport of chloride and thiocyanates.
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Model exhibits a deletion of the Cntnap2 gene and is useful in of studies autism, cell adhesion, and synaptic plasticity.
Cotton rat
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Model very sensitive to infectious agents of human origin. Ideal for research into the development of vaccines and gene therapy based on adenoviral vectors.
Disc1 Knockout Rat
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Model with a deletion in Disc1 gene for use in studies of schizophrenia, bipolar disorder and neuronal growth studies.
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Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.
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Model contains a biallelic disruption of the Faah and is useful in cannabioid, nocicepcin and pain research.
Fmr1 Knockout Rat
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Model exhibits the deletion of the FMR1 gene responsible for fragile X syndrome and autism.
Ldlr rat
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Knockout rats LDLR gene, with a much elevated serum cholesterol. Model for lipoprtein transport and cholesterol studies, type II diabetes, hypertension and atherosclerosis.
Leptin rat
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In vivo model obesity, diabetes, atherosclerosis and hypertension research. Homozygous rats do not express the leptin hormone.
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Double knockout contains deletion Lrrk1 and Lrrk2 genes. Ideal for Prkinson research and neuronal apoptosis.
Lrrk1 Knockout Rat
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Model with deletion of the Lrrk1 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
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Model with deletion of the Lrrk2 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
Mdr1a Knockout Rat
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Knockout model responsible for the production of galectin Lgals1, which can act as an autocrine negative growth factor regulating cell proliferation.
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Homozygous rat model with double Brcp-Mdr1a knockout. Useful in efflux research, tissue distribution, formulation and neurotoxicology studies.
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Rat model with knockout MDR1a i MDR 1b encodes P-glycoprotein. Used in clinical pharmacokinetics, pharmacodynamics, efficacy, neurotoxicology, multidrug resistance, efflox.
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Laboratory model used to study the mechanism of autism, Rett syndrome, and cognitive function.
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This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). Ideal for fragile X syndrome and autism research.
Mrp2 Rat
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Hyperbilirubinemia rat model used in efflux mechanism research.
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Model to study autism spectrum, schizophrenia and synaptic plasticity. Exhibit a deletion of the gene Nrxn1.
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Model of biallelic deletion of a gene Nlgn3 encoding a protein Neuroligin 3, which is linked with autism and Asperger's Syndrome.
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The model has the deleted gene organic anion transporter 1 OAT1. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
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The model has the deleted gene organic anion transporter 3 OAT3. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
SD Rat 2
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Knockout model encoding transporter OCT1, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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Knockout model encoding transporter OCT2, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene and is useful in nociceptin and discrimination among opioid receptor subtypes research.
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Model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Knockout homozygous are useful in pain, nociception and anelgesia research.
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Model with deletion of DJ-1 gene plays role in protecting neurons from oxidative stress and cell death. Ideal for Parkinson diseases and dopaminergic cell loss research.
Pink1 (Park6) Knockout
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Research model for Parkinson's disease and stress induced neurological disfunctions.
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Knockout model to study the role of nuclear receptors in the impact of carcinogenic substances, the compounds of xenobiotic metabolism and hepatotoxicity.
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Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.

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