Terapeutická oblast

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The model contains monoallelic deletion of the BDNF gene. Useful in the study of Alzheimer's, depression, pain, nerve growth, loss of memory.
bdnf rat alzheimers 4
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Knockout the gene encoding the ABC transporter, a critical in exporting pump bile salts.
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Knockout model encoding CAR having effects on induction of cytochrome p450s. It has applications in the study of hepatotoxicity, cholestasis and drug metabolism.
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Model with the lack of expression of the CFTR protein leads to cystic fibrosis and disruption of transport of chloride and thiocyanates.
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Model exhibits a deletion of the Cntnap2 gene and is useful in of studies autism, cell adhesion, and synaptic plasticity.
Cotton rat
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Model very sensitive to infectious agents of human origin. Ideal for research into the development of vaccines and gene therapy based on adenoviral vectors.
Disc1 Knockout Rat
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Model with a deletion in Disc1 gene for use in studies of schizophrenia, bipolar disorder and neuronal growth studies.
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Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.
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Model contains a biallelic disruption of the Faah and is useful in cannabioid, nocicepcin and pain research.
Fmr1 Knockout Rat
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Model exhibits the deletion of the FMR1 gene responsible for fragile X syndrome and autism.
Ldlr rat
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Knockout rats LDLR gene, with a much elevated serum cholesterol. Model for lipoprtein transport and cholesterol studies, type II diabetes, hypertension and atherosclerosis.
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Double knockout contains deletion Lrrk1 and Lrrk2 genes. Ideal for Prkinson research and neuronal apoptosis.
Lrrk1 Knockout Rat
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Model with deletion of the Lrrk1 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
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Model with deletion of the Lrrk2 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
Mdr1a Knockout Rat
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Knockout model responsible for the production of galectin Lgals1, which can act as an autocrine negative growth factor regulating cell proliferation.
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Homozygous rat model with double Brcp-Mdr1a knockout. Useful in efflux research, tissue distribution, formulation and neurotoxicology studies.
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Rat model with knockout MDR1a i MDR 1b encodes P-glycoprotein. Used in clinical pharmacokinetics, pharmacodynamics, efficacy, neurotoxicology, multidrug resistance, efflox.
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Laboratory model used to study the mechanism of autism, Rett syndrome, and cognitive function.
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This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). Ideal for fragile X syndrome and autism research.
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Charles River develops and produces monoclonal antibodies (in vitroproduction of hybridomas) in cooperation with Squarix Biotechnology GmbH. You have the choice between complete packages or individual development and production services.
Mrp2 Rat
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Hyperbilirubinemia rat model used in efflux mechanism research.
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Model to study autism spectrum, schizophrenia and synaptic plasticity. Exhibit a deletion of the gene Nrxn1.
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Model of biallelic deletion of a gene Nlgn3 encoding a protein Neuroligin 3, which is linked with autism and Asperger's Syndrome.
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The model has the deleted gene organic anion transporter 1 OAT1. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
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The model has the deleted gene organic anion transporter 3 OAT3. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
SD Rat 2
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Knockout model encoding transporter OCT1, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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Knockout model encoding transporter OCT2, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene and is useful in nociceptin and discrimination among opioid receptor subtypes research.
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Model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Knockout homozygous are useful in pain, nociception and anelgesia research.
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Model with deletion of DJ-1 gene plays role in protecting neurons from oxidative stress and cell death. Ideal for Parkinson diseases and dopaminergic cell loss research.
Pink1 (Park6) Knockout
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Research model for Parkinson's disease and stress induced neurological disfunctions.
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With dual experience in breeding and service provision, Charles River is a flexible and reactive partner throughout the entire antibody production process. We comprehensively conduct immunization protocols on a wide range of species from SPF rodents to large animals.
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Knockout model to study the role of nuclear receptors in the impact of carcinogenic substances, the compounds of xenobiotic metabolism and hepatotoxicity.
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Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.

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