Zvířecí modely

We are committed to providing you with high-quality genetically standardized models such as SPF (Specific Pathogen Free) and SOPF (Specific and Opportunistic Pathogen Free) animals which are free of select infectious agents and parasites. The terms SPF and SOPF are mare commonly used in continental Europe while, VAF Plus and VAF Elite are mare recognisable in the UK and North America. 
SPF = VAF Plus and SOPF = VAF Elite; they are based on the same monitoring programmes in terms of agents screened, number and age of animals screened, frequency of testing, and recycling policies. 

Ordering information - Download

Research models, products and services can be ordered with our customer service deparment, via telephone or mail.
Each order must be confirmed.
To do the order processing smoother we encourage to use our ordering form, which is available on your request.

Original Health Reports available online on the following webistes :

Charles River Laboratories - Health Reports 
Jackson Laboratories - Health Reports

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Quarantines are often required by animal facilities to screen incoming animals for unwanted pathogens prior to introduction, and often take place either in a designated quarantine space or at a third-party facility. Quarantines can assess the current animals’ health status and safeguard against a potential facility contamination.
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The model contains monoallelic deletion of the BDNF gene. Useful in the study of Alzheimer's, depression, pain, nerve growth, loss of memory.
bdnf rat alzheimers 4
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Knockout the gene encoding the ABC transporter, a critical in exporting pump bile salts.
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Knockout model encoding CAR having effects on induction of cytochrome p450s. It has applications in the study of hepatotoxicity, cholestasis and drug metabolism.
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Model with the lack of expression of the CFTR protein leads to cystic fibrosis and disruption of transport of chloride and thiocyanates.
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Model exhibits a deletion of the Cntnap2 gene and is useful in of studies autism, cell adhesion, and synaptic plasticity.
Cotton rat
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Model very sensitive to infectious agents of human origin. Ideal for research into the development of vaccines and gene therapy based on adenoviral vectors.
Disc1 Knockout Rat
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Model with a deletion in Disc1 gene for use in studies of schizophrenia, bipolar disorder and neuronal growth studies.
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Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.
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The integrity of your research is susceptible to compromise in the face of natural disaster, genetic drift, and microbial contamination. Our embryology services ensure that no matter the circumstances, you maintain the ability to access your original stock and keep your research moving forward. These options provide an alternative to maintaining live animals for strains that are not currently being used, but may be needed in the future.
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Model contains a biallelic disruption of the Faah and is useful in cannabioid, nocicepcin and pain research.
Fmr1 Knockout Rat
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Model exhibits the deletion of the FMR1 gene responsible for fragile X syndrome and autism.
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For years, our customers have entrusted us with the breeding and housing of their priceless research models, because they know relying on us to manage and maintain their outsourced colonies allows them to focus on their research. Our knowledgeable project managers are committed to achieving your research goals through regular communication and collaboration with their team. You can be confident that your animals are receiving the ultimate care from our skilled technical staff, and that project tasks will be carried out quickly and efficiently.
Ldlr rat
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Knockout rats LDLR gene, with a much elevated serum cholesterol. Model for lipoprtein transport and cholesterol studies, type II diabetes, hypertension and atherosclerosis.
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When a unique breeding colony stops producing, a researcher will face a significant challenge when trying to continue their experiment. Our line rescue service can diagnose, plan, and recover these breeding colonies, allowing research and breeding to continue to meet set goals.
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Double knockout contains deletion Lrrk1 and Lrrk2 genes. Ideal for Prkinson research and neuronal apoptosis.
Lrrk1 Knockout Rat
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Model with deletion of the Lrrk1 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
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Model with deletion of the Lrrk2 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
Mdr1a Knockout Rat
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Knockout model responsible for the production of galectin Lgals1, which can act as an autocrine negative growth factor regulating cell proliferation.
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Homozygous rat model with double Brcp-Mdr1a knockout. Useful in efflux research, tissue distribution, formulation and neurotoxicology studies.
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Rat model with knockout MDR1a i MDR 1b encodes P-glycoprotein. Used in clinical pharmacokinetics, pharmacodynamics, efficacy, neurotoxicology, multidrug resistance, efflox.
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Laboratory model used to study the mechanism of autism, Rett syndrome, and cognitive function.
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This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). Ideal for fragile X syndrome and autism research.
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Charles River develops and produces monoclonal antibodies (in vitroproduction of hybridomas) in cooperation with Squarix Biotechnology GmbH. You have the choice between complete packages or individual development and production services.
Mrp2 Rat
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Hyperbilirubinemia rat model used in efflux mechanism research.
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Model to study autism spectrum, schizophrenia and synaptic plasticity. Exhibit a deletion of the gene Nrxn1.
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Model of biallelic deletion of a gene Nlgn3 encoding a protein Neuroligin 3, which is linked with autism and Asperger's Syndrome.
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The model has the deleted gene organic anion transporter 1 OAT1. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
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The model has the deleted gene organic anion transporter 3 OAT3. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
SD Rat 2
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Knockout model encoding transporter OCT1, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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Knockout model encoding transporter OCT2, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene and is useful in nociceptin and discrimination among opioid receptor subtypes research.
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Model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Knockout homozygous are useful in pain, nociception and anelgesia research.
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Model with deletion of DJ-1 gene plays role in protecting neurons from oxidative stress and cell death. Ideal for Parkinson diseases and dopaminergic cell loss research.
Pink1 (Park6) Knockout
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Research model for Parkinson's disease and stress induced neurological disfunctions.
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With dual experience in breeding and service provision, Charles River is a flexible and reactive partner throughout the entire antibody production process. We comprehensively conduct immunization protocols on a wide range of species from SPF rodents to large animals.
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Our preconditioning services can help alleviate the space, time, and labor costs involved with refining a model to meet your unique research requirements. Whether you are looking for animals fed a special diet, altered through surgery, or reared to a certain age, Charles River has the state-of-the-art animal facilities, professional animal care, and robust model selection to deliver study-ready animals right to your door.
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Knockout model to study the role of nuclear receptors in the impact of carcinogenic substances, the compounds of xenobiotic metabolism and hepatotoxicity.
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Charles River continually invests in innovations and in sophisticated IVF techniques so animals can be produced more quickly and in greater quantities than with traditional methods.
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Overview Charles River can remove adventitious organisms, such as viruses, bacteria, and parasites, from mice and rats with our rederivation services. Rederived animals ar...
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Charles River helps clients select, customize, create, and maintain the right model for their studies using the latest technologies. Our expert staff can work with you from concept to model creation to deliver the research animals you require for your studies.
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Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.

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