Horizon

Laboratory specializing in genetic modification of lab rats by Zinc Finger Nuclease technology.
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Horizon

Horizon using SAGE® Labs technology is a world-class provider of next-generation research models, including knockout rat models, and extensive support services. Using proprietary platform technologies, Horizon specializes in genetic manipulation of in vivo systems for specialized R&D applications.

Horizon’s offerings are built around our proprietary translational genomics platform, a high-precision and flexible suite of gene editing tools able to alter almost any endogenous gene sequence of human or mammalian cell-lines. Based from that launch pad, Horizon now offers over 23,000 catalog products, almost all of which are based on the application of gene editing to generate cell lines that accurately model the disease-causing mutations found in genetically based diseases.

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Laboratory rabbit model with the lack of expression of ApoE responsible for the metabolism of lipids. Used to test atherogenesis, atherosclerosis, diabetes research.
ApoE rat
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Rat model Alzheimer's disease with ApoE knockout for a wide range of studies of type II diabetes, obesity, atherosclerosis, insulin resistance and hypertension.
APP Knockout Rat
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Rat model for Alzheimer's research, dementia and other neurodegenerative diseases.
bcrp rat
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Homozygous knockout BCRP with an increased exposure to BCRPspecific substrates. For applications of drug metabolism research, pharmacodynamics and pharmacokinetics, drug-drug interactions.
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The model contains monoallelic deletion of the BDNF gene. Useful in the study of Alzheimer's, depression, pain, nerve growth, loss of memory.
bdnf rat alzheimers 4
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Knockout the gene encoding the ABC transporter, a critical in exporting pump bile salts.
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Knockout model encoding CAR having effects on induction of cytochrome p450s. It has applications in the study of hepatotoxicity, cholestasis and drug metabolism.
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Model with the lack of expression of the CFTR protein leads to cystic fibrosis and disruption of transport of chloride and thiocyanates.
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Model exhibits a deletion of the Cntnap2 gene and is useful in of studies autism, cell adhesion, and synaptic plasticity.
Cotton rat
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Model very sensitive to infectious agents of human origin. Ideal for research into the development of vaccines and gene therapy based on adenoviral vectors.
Disc1 Knockout Rat
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Model with a deletion in Disc1 gene for use in studies of schizophrenia, bipolar disorder and neuronal growth studies.
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Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.

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