Horizon

Laboratory specializing in genetic modification of lab rats by Zinc Finger Nuclease technology.
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Model contains a biallelic disruption of the Faah and is useful in cannabioid, nocicepcin and pain research.
Fmr1 Knockout Rat
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Model exhibits the deletion of the FMR1 gene responsible for fragile X syndrome and autism.
Ldlr rat
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Knockout rats LDLR gene, with a much elevated serum cholesterol. Model for lipoprtein transport and cholesterol studies, type II diabetes, hypertension and atherosclerosis.
Leptin rat
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In vivo model obesity, diabetes, atherosclerosis and hypertension research. Homozygous rats do not express the leptin hormone.
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Double knockout contains deletion Lrrk1 and Lrrk2 genes. Ideal for Prkinson research and neuronal apoptosis.
Lrrk1 Knockout Rat
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Model with deletion of the Lrrk1 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
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Model with deletion of the Lrrk2 gene. Ideal for Parkinson's disease and neuronal apoptosis research.
Mdr1a Knockout Rat
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Knockout model responsible for the production of galectin Lgals1, which can act as an autocrine negative growth factor regulating cell proliferation.
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Homozygous rat model with double Brcp-Mdr1a knockout. Useful in efflux research, tissue distribution, formulation and neurotoxicology studies.
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Rat model with knockout MDR1a i MDR 1b encodes P-glycoprotein. Used in clinical pharmacokinetics, pharmacodynamics, efficacy, neurotoxicology, multidrug resistance, efflox.
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Laboratory model used to study the mechanism of autism, Rett syndrome, and cognitive function.
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This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). Ideal for fragile X syndrome and autism research.

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