Horizon

Laboratory specializing in genetic modification of lab rats by Zinc Finger Nuclease technology.
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Mrp2 Rat
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Hyperbilirubinemia rat model used in efflux mechanism research.
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Model to study autism spectrum, schizophrenia and synaptic plasticity. Exhibit a deletion of the gene Nrxn1.
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Model of biallelic deletion of a gene Nlgn3 encoding a protein Neuroligin 3, which is linked with autism and Asperger's Syndrome.
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The model has the deleted gene organic anion transporter 1 OAT1. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
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The model has the deleted gene organic anion transporter 3 OAT3. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
SD Rat 2
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Knockout model encoding transporter OCT1, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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Knockout model encoding transporter OCT2, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.
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This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene and is useful in nociceptin and discrimination among opioid receptor subtypes research.
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Model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Knockout homozygous are useful in pain, nociception and anelgesia research.
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Model with deletion of DJ-1 gene plays role in protecting neurons from oxidative stress and cell death. Ideal for Parkinson diseases and dopaminergic cell loss research.
Pink1 (Park6) Knockout
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Research model for Parkinson's disease and stress induced neurological disfunctions.
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Knockout model to study the role of nuclear receptors in the impact of carcinogenic substances, the compounds of xenobiotic metabolism and hepatotoxicity.

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