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11BHSD2 mouse

11BHSD2 Mouse

11BHSD2 mouse

Transgenic model to study cardiac hypertrophy and heart failure.

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  • Description

11BHSD2 mouse

Nomenclature: C57BL/6NCrl-Tg(αMhc-Hsd11b2)

Origin: The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Transferred to Charles River under exclusive license from Pfizer, Inc., in 2011.

Coat color: Black

Ideal for: Cardiac hypertrophy, heart failure

Strain code: 510 HE, 511 HO, 512 WT. This model is cryopreserved.