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ApoE knockout rabbit

ApoE knockout rabbit

Laboratory rabbit model with the lack of expression of ApoE responsible for the metabolism of lipids. Used to test atherogenesis, atherosclerosis, diabetes research.

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  • Description

ApoE knockout rabbit

Nomenclature: NZW- ApoE tm1sage

Genotype: Homozygous

Description: Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease.

Research applications:

  • atherogenesis
  • atherosclerosis
  • hypertension
  • insulin resistance
  • lipoprotein/cholesterol transportation
  • metabolism (triglyceride/cholesterol)
  • obesity
  • type II diabetes

Characteristic:

  • 8 bp deletion within Exon 3
  • homozygous knockouts exhibit complete loss of ApoE protein via Western blot
  • at four months of age, ApoE knockout rabbits demonstrate serum cholesterol levels 2-5x greater than wildtype
  • at four and five months of age, ApoE knockout rabbits demonstrate triglyceride levels up to 2x greater than wildtype
  • bckground strain: New Zealand White

Coat color: White, albino.

Strain code: TGON0001

Bred in: US

Additional information: ApoE is essential for the normal metabolism of lipids. It is expressed in the liver, intestines and brain, preventing the accumulation of cholesterol-rich particles in plasma. Widely studied for its role in cardiovascular disease and lipoprotein transport, it has more recently been implicated in Alzheimer’s disease and cognition, making this a useful model for the study of atherosclerosis, Alzheimer’s and nerve injury.