ApoE knockout rat

ApoE rat

ApoE knockout rat

Manufacturer: 

Rat model Alzheimer's disease with ApoE knockout for a wide range of studies of type II diabetes, obesity, atherosclerosis, insulin resistance and hypertension.

Add to quote request
  • Description

ApoE knockout rat

Nomenclature: SD- ApoE tm1sage

Genotype: Homozygous

Description: Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.

Research applications

  • Alzheimer's disease
  • atherogenesis
  • atherosclerosis
  • hypertension
  • insulin resistance
  • lipoprotein/Cholesterol transportation
  • metabolism (Triglyceride/Cholesterol)
  • obesity
  • type II diabetes

Characteristic

  • 16 bp deletion within Exon 3 on chromosome 1
  • homozygous knockouts exhibit complete loss of ApoE protein via Western blot
  • administration of high fat diets to ApoE KO rats has resulted in significantly reduced lifespan. SAGE Labs does not recommend
  • administering high fat diets to ApoE KO rats.
  • at an early age (5- and 10-week-old), ApoE knockouts demonstrate significantly higher serum cholesterol
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRA3710

Bred in: US

Recommended diet: Totally Pathogen Free diet by Altromin

Additional information: ApoE is essential for the normal metabolism of lipids. It is expressed in the liver, intestines and brain, preventing the accumulation of cholesterol-rich particles in plasma. Widely studied for its role in cardiovascular disease and lipoprotein transport, it has more recently been implicated in Alzheimer’s disease and cognition, making this a useful model for the study of atherosclerosis, Alzheimer’s and nerve injury.