APP knockout rat

APP Knockout Rat

APP knockout rat


Rat model for Alzheimer's research, dementia and other neurodegenerative diseases.

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APP knockout rat

Nomenclature: SD- App tm1sage

Genotype: Cryopreserved as heterozygous embryosHomozygota

Description:  This model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. APP can be cleaved by the beta and gamma secretases, forming beta amyloid. Beta amyloid can self-aggregate to form amyloid plaques, one of the hallmarks of Alzheimer's disease.


  • homozygous knockout rats exhibit complete loss of protein
  • Sprague Dawley background strain

Research applications

  • Alzheimer's disease
  • neurodegeneration
  • memory loss
  • dementia
  • synaptic formation and repair

Coat color: Biały, albino.

Strain code: TGRS5460

Bred in: US

Additional information: Mutations in APP have been associated with familial Alzheimer's disease. APP is concentrated at neuronal synapses, however, its precise function has yet to be elucidated.

Cryopreserved - please inquire for pricing and availability.

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Pasza bytowa Totally Pathogen Free dla szczurów i myszy laboratoryjnych.