Bcrp knockout rat

bcrp rat

Bcrp knockout rat

Homozygous knockout BCRP with an increased exposure to BCRPspecific substrates. For applications of drug metabolism research, pharmacodynamics and pharmacokinetics, drug-drug interactions.

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  • Description

Bcrp knockout rat

Nomenclature: SD- Abcg2 tm1sage

Genotype: Homozygous

Description: BCRP plays a protective role in neurotoxicity by limiting the efflux of xenobiotics into the brain. Homozygous null rats demonstrate increased exposure in the brain and plasma when dosed with BCRP-specific substrates.

Research applications:

  • DMPK assay
  • efflux assay
  • neurotoxicology
  • formulation
  • drug-drug interactions
  • drug resistance
  • blood brain barrier efflux
  • efficacy assay


  • biallelic 588 bp deletion within Abcg2 gene
  • homozygous knockouts display total loss of protein via Western blot
  • increased oral bioavailability of BCRP-specific substrates
  • background strain: Sprague-Dawley

Coat color: White, albino.

Recommended diet: Purina #5008

Strain code: TGRS4200

Bred in: US

Additional information: Loss of function of Bcrp leads to improper transport of drugs across epithelial cells and increased bioavailability of Bcrp substrates. This model is useful for studying metabolism of xenobiotic compounds, tissue distribution, DMPK, efficacy, formulation, and blood brain barrier efflux.