CFTR knockout rat

CFTR knockout rat

Manufacturer: 

Model with the lack of expression of the CFTR protein leads to cystic fibrosis and disruption of transport of chloride and thiocyanates.

Add to quote request
  • Description

CFTR knockout rat

Cryopreserved – please inquire for pricing and availability.

Nomenclature:  SD- Cftr tm1SAGE

Genotype: Homozygous

Description: CFTR knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (CFTR), resulting in loss of protein expression.

Research applications

  • cystic fibrosis
  • chloride transport
  • thiocyanide transport

Characteristic

  • homozygous knockouts exhibit complete loss of protein via Western blot
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TBD

Bred in: US

Additional information: CFTR knockout rats lack CFTR protein as demonstrated by western blot. CFTR KO rats develop intestinal obstructions shortly after weaning leading to weight loss and mortality. CFTR KO rats also exhibit decreased trachea circumference as well as submucosal gland volume. Stored nasal mucus volume is increased. Abnormal dentition is observed, and the vas deferens is absent in male CFTR knockout rats.