Disc1 knockout rat

Disc1 Knockout Rat

Disc1 knockout rat

Manufacturer: 

Model with a deletion in Disc1 gene for use in studies of schizophrenia, bipolar disorder and neuronal growth studies.

Add to quote request
  • Description

Disc1 knockout rat

Nomenclature: SD- Disc1 tm1sage

Genotype: Homozygous

Description: This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.

Characteristics

  • disc1 is involved in neuronal growth and cortical development
  • the protein also regulates the proliferation of embryonic and adult neuronal progenitor cells through the GSK3/β-catenin pathway
  • preliminary reports suggest impaired prepulse inhibition in Disc1 knockout rats
  • background strain: Sprague-Dawley

Research applications

  • schizophrenia
  • bipolar disorder
  • neuronal growth and transport studies

Coat color: White, albino.

Strain code: TGRA3640

Bred in: US

Additional information:

Disc1 is involved in neuronal growth and cortical development. The protein also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3/β-catenin pathway. Disc1 was first identified through a translocation that segregates with schizophrenia and related psychiatric disorders in a large Scottish family, making this model useful for the study of Schizophrenia, Bipolar disorder and neuronal development.

Model is cryopreserved – please inquire for pricing and availability.