Dopamine transporter (DAT)-CRE rat

Dopamine transporter (DAT)-CRE rat

Model with expresion of Cre recombinase. For applications in optogenetic, expression and nockout recombined genes and DREADD.

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  • Description

Dopamine transporter (DAT)-CRE rat

Nomenclature: SD- Slc6a3-cre tm1sage

Genotype: Homozygous

Description: This model expresses cre-recombinase under the control of the endogenous dopamine transporter promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of DAT. The DAT-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.

Research applications

  • optogenetics
  • designer receptors exclusively activated by designer drugs DREADD
  • expression/knockout of floxed genesnociception

Characteristics

  • Cre recombinase driven by endogenous DAT promoter
  • targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRA8330

Bred in: US