FAAH knockout rat

FAAH knockout rat

Model contains a biallelic disruption of the Faah and is useful in cannabioid, nocicepcin and pain research.

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  • Description

FAAH knockout rat

Nomenclature: SD- FAAH tm1sage

Genotype: Homozygous

Description: This model contains a biallelic disruption of the Faah gene encoding the fatty acid amide hydrolase. FAAH is a serine hydrolase responsible for the breakdown of endocannabinoids. This model is useful for the study of cannabinoid biology including nociception.

Research applications

  • pain
  • nociception
  • analgesia
  • cannabinoids


  • homozygous knockout rats exhibit complete loss of protein
  • FAAH KO rats show an increased fear/startle reaction as observed in a functional observational battery (Irwin)
  • FAAH KO rats show normal sensitivity to thermal pain via hot plate assay
  • Sprague Dawley background strain

Coat color: White, albino.

Strain code: TGRA6300

Bred in: US