Fmr1 knockout rat

Fmr1 Knockout Rat

Fmr1 knockout rat

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Model exhibits the deletion of the FMR1 gene responsible for fragile X syndrome and autism.

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  • Description

Fmr1 knockout rat

Nomenclature: SD- Fmr1 tm1sage

Genotype: Homozygous females, hemizygous males.

Description: This model contains a deletion of the Fragile X mental retardation 1 gene (Fmr1). Mutations in Fmr1 result in Fragile X syndrome, the leading monogenic cause of autism, making this rat useful for the study of both Fragile X syndrome and autism.

Research applications

  • autism
  • fragile X syndrome

Characteristics

  • this model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine
  • preliminary results suggest Fmr1 knockout rats possess perseverative chewing behavior and decreased juvenile play
  • homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
  • an expansion of CGG trinucleotide repeat in Fmr1 has been implicated in Fragile X syndrome
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: GRS5390

Bred in: US

Additional information:

The X-linked gene Fmr1 produces the fragile X metal retardation protein, or FMRP. FMRP is essential for normal mental development. An expansion of the trinucleotide CGG repeat in the Fmr1 gene is responsible for fragile X syndrome, a syndrome characterized by autism and mental disability.