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GLUT 4 Mouse

GLUT 4 Mouse

GLUT 4 Mouse

Model for a wide range of diabetes studies.

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GLUT 4 Mouse

Nomenclature: BKS.Cg-Dock7m +/+ Leprdb Tg(SLC2a4)1Pfi

Origin: Transgenic mice were produced by injecting an 11.8 kb (NotI fragment) human genomic GLUT 4 transgene including a 5.3 kb of 5’flanking sequence and an SV40 polyadenylation sequence into the pronuclei of embryos from matings of C57BL/KsJ-m+/+ males and superovulated females. The embryos were then transferred to pseudopregnant CD-1 females. Founder mice were identified by PCR of total genomic DNA to obtain two mice with the recessive obese phenotype (+db/+db) and two founders with the recessive misty coat color (m+/m+). Independent lines were established by backcrossing lean founder mice with C57BL/KsJ-m+/db+ mates. Transferred to Charles River under exclusive license in 2011.

Coat color: Black

Ideal for: Diabetes

Strain code: 513 HE, 514 HO, 515 WT. This model is cryopreserved.