Ldlr knockout rat

Ldlr rat

Ldlr knockout rat

Manufacturer: 

Knockout rats LDLR gene, with a much elevated serum cholesterol. Model for lipoprtein transport and cholesterol studies, type II diabetes, hypertension and atherosclerosis.

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  • Description

Ldlr knockout rat

Cryopreserved – Please inquire for pricing and availability.

Nomenclature: SD- Ldlr tm1sage

Genotype: Homozygous

Description: The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels.

Research applications

  • atherogenesis
  • atherosclerosis
  • hypertension
  • insulin resistance
  • lipoprotein/Cholesterol transportation
  • metabolism (Triglyceride/Cholesterol)
  • obesity
  • type II diabetes

Characteristic

  • this model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8
  • homozygous knockout rats display loss of LDLR protein via Western blot
  • homozygous knockout rats have increased body weight as compared to wild type
  • homozygous knockout rats show significantly elevated serum cholesterol levels
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRS4060

Bred in: US

Recommended diet: Totally Pathogen Free diet by Altromin

Additional information: Ldlr mediates the endocytosis of cholesterol-rich low-density lipoproteins (LDL) and is important for the proper regulation of LDL circulation within the blood. Expressed in the liver, loss of function of Ldlr leads to accumulation of excess LDL, which directly contributes to atherosclerosis, making this a useful model for the study of cardiovascular disease.