Leptin knockout rat - KiloRat™

Leptin rat

Leptin knockout rat - KiloRat™


In vivo model obesity, diabetes, atherosclerosis and hypertension research. Homozygous rats do not express the leptin hormone.

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  • Publications

Leptin knockout rat - KiloRat™

Cryopreserved – please inquire for pricing and availability.

Nomenclature: SD- Lep tm1sage

Genotype: Homozygous

Description: Leptin is essential for energy intake and expenditure. It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appetite leading to severe obesity and abnormal metabolism, making this a useful model for the study of lifestyle diseases, such as obesity, diabetes, atherosclerosis, high cholesterol and high blood pressure.

Research applications:

  • obesity
  • type II diabetes
  • atherogenesis
  • atherosclerosis
  • hypertension
  • insulin resistance
  • lipoprotein/cholesterol transportation
  • metabolism (triglyceride/cholesterol)


  • this model possesses a 151 bp deletion within Exon 1 on chromosome 4
  • homozygous knockout rats display loss of Leptin protein via Western blot
  • homozygous knockout rats demonstrate significant weight gain compared to wild type littermates
  • homozygous knockout rats demonstrate insulin resistance
  • homozygous knockout rats show greatly elevated serum cholesterol levels
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRA3780

Bred in: US

Recommended diet: Totally Pathogen Free diet by Altromin

Creation and preliminary characterization of a leptin knockout rat.

Sergio Vaira, Chang Yang, Aaron McCoy, Kelly Keys, Shurong Xue, Edward J Weinstein, Deborah V Novack, and Xiaoxia Cui
Endocrinology 153(11):5622 (2012) PMID 22948215 PMCID PMC3473197