Lrrk2 knockout rat

Lrrk2 knockout rat

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Model with deletion of the Lrrk2 gene. Ideal for Parkinson's disease and neuronal apoptosis research.

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  • Description
  • Publications

Lrrk2 knockout rat

Nomenclature: LEH- Lrrk2 tm1sage

Genotype: Homozygous

Origin: Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson’s disease. This model is useful in understanding Lrrk2 biology.

Characteristics

  • homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
  • Lrrk2 knockout rats display dark kidneys, similar to observations made in Lrrk2 knockout mice
  • Lrrk2 knockout rats are significantly larger than wild type controls
  • background Strain: Long Evans Hooded

Research applications

  • Parkinson’s disease
  • neuronal apoptosis

Coat color: White with black cover, exceptional white with brown cover.

Strain code: TGRL4620

Bred in: US

Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

Daniel Ness, Zhao Ren, Shyra Gardai, Douglas Sharpnack, Victor J. Johnson, Richard J. Brennan, Elizabeth F. Brigham, Andrew J. Olaharski
PLOS Published: June 14, 2013 DOI: 10.1371/journal.pone.0066164


Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

Marco A. S. Baptista, Kuldip D. Dave, Mark A. Frasier, Todd B. Sherer, Melanie Greeley, Melissa J. Beck, Julie S. Varsho, George A. Parker, Cindy Moore, Madeline J. Churchill, Charles K. Meshul, Brian K. Fiske
PLoS One. 2013 Nov 14;8(11):e80705. doi: 10.1371/journal.pone.0080705. eCollection 2013.


Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Paul Davies, Kelly M. Hinkle, Nour N. Sukar, Bryan Sepulveda, Roxana Mesias, Geidy Serrano, Dario R. Alessi, Thomas G. Beach, Deanna L. Benson, Charles L. White, Rita M. Cowell, Sonal S. Das, Andrew B. West, Heather L. Melrose†,2,3
Biochem J. 2013 Jul 1; 453(Pt 1): 101–113