Mdr1a knockout rat

Mdr1a Knockout Rat

Mdr1a knockout rat

Knockout model responsible for the production of galectin Lgals1, which can act as an autocrine negative growth factor regulating cell proliferation.

Add to quote request
  • Description
  • Publications

Mdr1a knockout rat

Cryopreserved – please inquire for pricing and availability.

Nomenclature:  SD- Abcb1atm1sage

Genotype: Homozygous

Description: P-glycoprotein plays a critical role in efflux for both brain and liver. Homozygous null Mdr1a rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp-specific substrates.Galectins have been implicated in inflammation and cancer, and are useful targets for development of new anti-inflammatory and anticancer therapies. LGALS1 (GAL1) may act as an autocrine negative growth factor that regulates cell proliferation.

Research applications

  • DMPK assay
  • PK/PD
  • efflux assay
  • neurotoxicology
  • formulation
  • drug-drug interactions
  • drug resistance
  • blood brain barrier efflux
  • efficacy

Characteristic

  • homozygous knockout rats display loss of Lgals1 protein via Western blot
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRS3570

Bred in: US

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics

Maciej J. Zamek-Gliszczynski, David W. Bedwell, Jing Q. Bao,d J. William Higgins
DMD September 2012 vol. 40 no. 9 1825-1833


Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice

Christoffer Bundgaard, Christian Jes Nyberg Jensen,nd Mats Garmer
DMD March 2012 vol. 40 no. 3 461-466


Minor Compensatory Changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats do not Detract from their General Utility in the Study of Transporter-mediated Pharmacokinetics

Maciej J Zamek-Gliszczynski, Keith M Goldstein, April Paulman, Thomas K Baker, Timothy P Ryan
DMD April 8, 2013 dmd.113.051409