MeCP2 knockout rat

MeCP2 knockout rat

Laboratory model used to study the mechanism of autism, Rett syndrome, and cognitive function.

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  • Description

MeCP2 knockout rat

Nomenclature: SD- Mecp2 tm1sage

Genotype: Heterozygous females

Description: This model contains a deletion of the methyl-CpG-binding protein (MeCP2)and is useful for the study of Rett syndrome. Mutations in MeCP2 have been linked to the development of Rett syndrome, a leading cause of intellectual disabilities in girls.

Research applications

  • autism
  • Rett syndrome
  • cognition

Characteristics

  • knockout rats exhibit complete loss of target protein as demonstrated by Western blot
  • mutations in methyl-CpG-binding protein (MeCP2) result in Rett syndrome, a leading cause of intellectual disabilities in girls
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRA6090

Bred in: US