mGluR5 knockout rat

mGluR5 knockout rat

This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). Ideal for fragile X syndrome and autism research.

Add to quote request
  • Description

mGluR5 knockout rat

Nomenclature: SD- Grm5 tm1sage

Genotype: Homozygous

Description: This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). mGluR5 function is altered in Fragile X syndrome, and mGluR5 has emerged as a promising drug target for both Fragile X syndrome and autism spectrum disorders.

Research applications

  • autism
  • fragile X syndrome
  • cognition
  • schizophrenia
  • anxiety
  • pain

Characteristics

  • mGluR5 is implicated in the neuropharmacology of cognition, anxiety, addiction and pain
  • the function of this receptor is altered in Fragile X syndrome
  • mGlurR5 antagonists are being pursued as potential therapeutics for Fragile X syndrome and autism spectrum disorders
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRA6020

Bred in: US