MotoRater

MotoRater cały system TSE Systems

MotoRater

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Automatic, fully computerized system for motor function test of laboratory rats and mice.

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  • Description
  • Publications

MotoRater

The TSE MotoRater represents a novel set-up for standardized quantitative and objective kinematic evaluation of animal movement types not restricted to mere foot prints. The unique modular design of the TSE MotoRater allows the investigation of rats and mice during skilled walking on a ladder or beam, overground walking, wading and swimming. Objective, sensitive and specific readouts of locomotor impairments, recovery or improvement can be obtained. Moreover, movements of all relevant body parts, i.e. forelimbs, hindlimbs, trunk and tail can be assessed and correlated, leading to a complete profile of the animal's motor abilities. As a consequence, the TSE MotoRater is an improvement in the standardization of behavioral assessment of rodent locomoter skills by replacing traditional scoring methods. All these measurements can be taken by a single experimenter.

An arrangement of mirrors allows the recording of animals from the left and right side and from below at the same time. A color-based tracking software allows automatic tracking of an unlimited number of markers, such as knee, toe, hip or iliac crest and other skin overlying anatomical landmarks. Therefore, a variety of behaviorally meaningful parameters can be obtained and are accompanied by detailed biomechanical measurements.

MotoRater features

  • quantitative and objective evaluation of locomotor functions in rats and mice using high-speed video tracking
  • TSE Motion High-Speed Video Analysis Software for kinematic image based motion analysis also available as additional single license for simultaneous analysis
  • standardized modular system allows high flexibility of testing rodents during walking, wading and swimming
  • biomechanical assessments of all body parts at the same time
  • high efficiency and throughput
  • measurements by single investigator possible

 

2014

Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits.

Borgius L, Nishimaru H, Caldeira V, Kunugise Y, Löw P, Reig R, Itohara S, Iwasato T, Kiehn O.
J Neurosci 2014; 34(11):3841-53


High-impact, self-motivated training within an enriched environment with single animal tracking dose-dependently promotes motor skill acquisition and functional recovery.

Starkey ML, Bleul C, Kasper H, Mosberger AC, Zörner B, Giger S, Gullo M, Buschmann F, Schwab ME.
Neurorehabil Neural Repair 2014; 28(6): 594-605


Chasing central nervous system plasticity: the brainstem’s contribution to locomotor recovery in rats with spinal cord injury.

Zörner B, Bachmann LC, Filli L, Kapitza S, Gullo M, Bolliger M, Starkey ML, Röthlisberger M, Gonzenbach RR, Schwab ME.
Brain 2014; 137(Pt 6):1716-32


 

 

2013

Dual-mode operation of neuronal networks involved in left–right alternation.

Talpalar AE, Bouvier J, Borgius L, Fortin G, Pierani A, Kiehn O.
Nature 2013; 500(7460):85-8


 

 

2011

Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Séquard syndrome.

Filli L, Zörner B, Weinmann O, Schwab ME.
Brain 2011; 134:2261-2273


 

2010

Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents.

Zörner B, Filli L, Starkey ML, Gonzenbach R, Kasper H, Röthlisberger M, Bolliger M, Schwab ME.
Nat Methods 2010; 7(9):701-8