Mrp2 knockout rat

Mrp2 Rat

Mrp2 knockout rat

Hyperbilirubinemia rat model used in efflux mechanism research.

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  • Description
  • Publications

Mrp2 knockout rat

Nomenclature: SD- Abcc2 tm1sage

Genotype: Homozygous

Description: Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.

Research applications

  • DMPK
  • PK/PD
  • formulation
  • efflux assays
  • efficacy
  • drug-drug interactions
  • tissue distribution
  • Dubin-Johnson syndrome

Characteristics

  • biallelic 726 bp deletion within Abcc2 gene
  • homozygous knockouts display total loss of protein via Western blot
  • decreased transport of endogenous glutathione
  • hyperbilirubinemia
  • background strain: Sprague-Dawley

Coat color: White, albino.

Recommended diet: Purina #5008

Strain code:  TGRS4340

Bred in: US

Additional information: Mrp2 is expressed in the liver and functions in biliary transport. The gene’s substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays.

Minor Compensatory Changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats do not Detract from their General Utility in the Study of Transporter-mediated Pharmacokinetics

Maciej J Zamek-Gliszczynski, Keith M Goldstein, April Paulman, Thomas K Baker, and Timothy P Ryan
DMD April 8, 2013 dmd.113.051409


Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics

Maciej J. Zamek-Gliszczynski, David W. Bedwell, Jing Q. Bao and J. William Higgins
DMD September 2012 vol. 40 no. 9 1825-1833