Multi Conditioning System

Multi Conditioning System


Multi Conditioning System is multi-purpose modular test platform on today’s market accommodating nine standard conditioning paradigms for the evaluation of learning, memory, emotion and stres.

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Multi Conditioning System

One system – nine paradigms. The TSE Multi Conditioning System is the first multi-purpose modular test platform on today’s market accommodating nine standard conditioning paradigms for the evaluation of learning, memory, emotion and stress-related behaviors in mice and rats. The universal base unit can be extended easily with a large variety of modular arenas and accessories, thus providing unique flexibility. More than that – The Multi Conditioning System is highly cost-effective especially if several paradigms are needed, and it saves valuable space in the laboratory since one base unit supports all nine paradigms.The combination is more than the sum of its components!

The following paradigms can be assessed with the Multi Conditioning System:

  • fear conditioning
  • panic response
  • active and passive avoidance
  • learned helplessness
  • conditioned place preference
  • latent inhibition
  • light-dark test
  • open field
  • locomotor activity

Recommended reading:
Gräff et al., Nature 483(7388), 2012 
An epigenetic blockade of cognitive functions in the neurodegenerating brain

Using the fear conditioning module of TSE Systems´ Multi Conditioning System, this group at MIT, Cambridge, MA was able to demonstrate that cognitive abilities are blocked by epigenetic mechanisms and reinstated by a novel modus operandi.

Key features

  • High-resolution light-beam frame for movement detection
  • Selection of sound, noise & light stimuli and electric shocks
  • Variable compartment design for tactile and visual discrimination
  • Versatile design of experiments for simultaneous operation in multiple chambers
  • Common software structure for all paradigms guarantees highest user-friendliness
  • Software features in compliance with GLP requirements
  • Simultaneous video monitoring from up to 2 angles, freely adjustable camera position
  • LARGE (mice & rats combined) or SMALL (mice only) system




DPP4-deficient congenic rats display blunted stress, improved fear extinction and increased central NPY.

Canneva F, Golub Y, Distler J, Dobner J, Meyer S, von Hörsten S
Psychoneuroendochrinology 2015; 53:195-206



Mouse social stress induces increased fear conditioning, helplessness and fatigue to physical challenge together with markers of altered immune and dopamine function.

Azzinnari D, Sigrist H, Staehli S, Palme R, Hildebrandt T, Leparc G, Hengerer B, Seifritz E, Pryce CR.
Neuropharmacology 2014; 85:328-41

Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.

Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, Haggarty SJ, Tsai LH
Cell 2014; 156(1-2):261-76

Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet.

Örd T, Innos J, Lilleväli K, Tekko T, Sütt S, Örd D, Kõks S, Vasar E, Örd T.
PLoS One 2014; 9(4):e94691

Lsamp is implicated in the regulation of emotional and social behavior by use of alternative promoters in the brain.

Philips MA, Lilleväli K, Heinla I, Luuk H, Hundahl CA, Kongi K, Vanaveski T, Tekko T, Innos J, Vasar E.
Brain Struct Funct 2014; Epub ahead of print

Dominant β-catenin mutations cause intellectual disability withrecognizable syndromic features.

Tucci V, Kleefstra T, Hardy A, Heise I, Maggi S, Willemsen MH, Hilton H, Esapa C, Simon M, Buenavista MT, McGuffin LJ, Vizor L, Dodero L, Tsaftaris S, Romero R, Nillesen WN, Vissers LE, Kempers MJ, Vulto-van Silfhout AT, Iqbal Z, Orlando M, Maccione A, Lassi G, Farisello P, Constestabile A, Tinarelli F, Nieus T,Raimondi A, Greco B, Cantatore D, Gasparini L, Berdondini L, Bifone A, Gozzi A, Wells S, Nolan PM
J Clin Invest 2014;124(4):1468-82



Effects of repeated adolescent stress and serotonin transporter gene partial knockout in mice on behaviors and brain structures relevant to major depression.

Spinelli S, Müller T, Friedel M, Sigrist H, Lesch KP, Henkelman M, Rudin M, Seifritz E, Pryce CR
Front Behav Neurosci 2013; 7:215




An epigenetic blockade of cognitive functions in the neurodegenerating brain.

Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH.
Nature 2012; 483(7388): 222-6

Establishing a learned-helplessness effect paradigm in C57BL/6 mice: Behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se.

Pryce CR, Azzinnari D, Sigrist H, Geschwind T, Lesch KP, Seifritz E.
Neuropharmacology 2012; 62(1): 358-372