Neuroligin 3 (Nlgn3) knockout rat

Neuroligin 3 (Nlgn3) knockout rat

Model of biallelic deletion of a gene Nlgn3 encoding a protein Neuroligin 3, which is linked with autism and Asperger's Syndrome.

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  • Description
  • Publications

Neuroligin 3 (Nlgn3) knockout rat

Nomenclature: SD- Nlgn3 tm1sage

Genotype: Hemizygous males, homozygous females

Description: This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger’s syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders.

Research applications:

  • autism
  • Asperger’s syndrome
  • synaptic plasticity

Characteristics

  • this model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine
  • preliminary results suggest that Nlgn3 knockout rats are less anxious and exhibit decreased juvenile play, deficits in sensorimotor gating and increased perseverative behaviors
  • homozygous knockout rats exhibit complete loss of target protein via Western blot
  • mutations in Nlgn3 have been associated with autism and Asperger’s syndrome
  • Nlgn3 is a member of the broader neuroligins, neuronal cell surface proteins thought to play a role in synaptic plasticity
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRS6650

Bred in: US

Additional information:

Neuroligins are neuronal cell-surface proteins that bind with beta neurexins, spanning synapses. Neuroligins may play a role in synaptic plasticity and mutations in neuroligin 3 have been associated with autism and Asperger syndrome.

Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders.

Hamilton SM, Green JR, Veeraragavan S, Yuva L, McCoy A, Wu Y, Warren J, Little L, Ji D, Cui X, Weinstein E, Paylor R.
Behav Neurosci. 2014 Apr;128(2):103-9. doi: 10.1037/a003598