Oct2 knockout rat

Oct2 knockout rat

Knockout model encoding transporter OCT2, a key role in the uptake of xenobiotics from hepatocytes. It has applications in toxicity and metabolism of the liver.

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  • Description

Oct2 knockout rat

Cryopreserved – Please inquire for pricing and availability.

Nomenclature: SD- Slc22a1 tm1sage

Genotype: Cryopreserved as heterozygous embryos

Description: This model contains a biallelic deletion within the Slc22a2 solute carrier family 22 (organic cation transporter), member 2, encoding for the basolateral hepatocyte uptake transporter OCT2.

Research applications

  • drug transport
  • drug-drug interactions
  • drug metabolism
  • hepatotoxicity

Characteristics

  • Oct1 (-/-) rats have increased exposure to specific substrates

Coat color: White, albino.

Recommended diet: Purina #5008

Strain code:  TGRS6580

Bred in: US

Additional information: Oct2 is involved in disposition and excretion through its role in xenobiotic uptake in the basolateral membrane of the liver. Polymorphisms within the gene also have clinical relevance – making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.