Oprm1 knockout rat

Oprm1 knockout rat

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This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene and is useful in nociceptin and discrimination among opioid receptor subtypes research.

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  • Description

Oprm1 knockout rat

Nomenclature: SD- OPRM1 tm1sage

Genotype: Homozygous

Description: This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene, leading to an early stop codon in exon 3. Oprm1 encodes the mu opioid receptor 1 (MOR), the major target of most clinically used opioids. This model is useful for applications investigating nociception, and is particularly useful for discrimination among opioid receptor subtypes.

Research applications

  • nociception
  • pain
  • analgesia
  • addiction

Characteristics

  • 11 base pair deletion in exon 2
  • early stop codon in exon 3
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRA8540

Bred in: US