Oprm1 knockout rat

Nomenclature: SD- OPRM1 ^tm1sage

Genotype: Homozygous

Description: This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene, leading to an early stop codon in exon 3. Oprm1 encodes the mu opioid receptor 1 (MOR), the major target of most clinically used opioids. This model is useful for applications investigating nociception, and is particularly useful for discrimination among opioid receptor subtypes.

Research applications

• nociception
• pain
• analgesia
• addiction

Characteristics

• 11 base pair deletion in exon 2
• early stop codon in exon 3
• background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRA8540

Bred in: US