p75NTR knockout rat

p75NTR knockout rat

Model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Knockout homozygous are useful in pain, nociception and anelgesia research.

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  • Description

p75NTR knockout rat

Nomenclature: SD- Ngfr tm1sage

Genotype: Homozygous

Description: This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research.

Research applications

  • pain
  • nociception
  • analgesia
  • neruonal development

Characteristics

  • homozygous knockout rats exhibit complete loss of p75NTR protein
  • p75NTR knockout rats show hyposensitivity to thermal pain via hot plate assay
  • p75NTR knockout rats show increased reactivity to touch in a functional observational battery (Irwin)
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRS5670

Bred in: US