Park7 (DJ-1) knockout rat

Park7 (DJ-1) knockout rat

Model with deletion of DJ-1 gene plays role in protecting neurons from oxidative stress and cell death. Ideal for Parkinson diseases and dopaminergic cell loss research.

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  • Description
  • Publications

Park7 (DJ-1) knockout rat

Nomenclature: LEH- Park7 tm1sage

Genotype: Homozygous

Origin: Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park7 (Parkinson disease [autosomal recessive, early onset] 7) gene, also known as DJ-1. Park7 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.

Characteristics

  • homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
  • approximately 30% of DJ-1 knockout rats show a hindlimb-dragging phenotype that emerges at 4–6 weeks of age and worsens at 5 months
  • DJ-1 knockout rats show impaired open-field mobility at 8 months of age
  • DJ-1 knockout rats show gait impairments at 8 months of age
  • preliminary reports have suggested DJ-1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age
  • background strain: Long Evans Hooded

Research applications

  • Parkinson’s disease
  • dopaminergic cell toxicity

Coat color: White with black cover, exceptional white with brown cover.

Strain code: TGRL4830

Bred in: US

Additional information: In humans, loss of function of Park7 leads to a form of early-onset Parkinson’s disease. This occurs due to the role Park7 plays in protecting neurons from oxidative stress and cell death, making this an ideal model for the study of Parkinson’s disease.

Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats

Jianjun Suna, Evguenia Kouranovac, Xiaoxia Cuic, Robert H. Macha, Jinbin Xu
Neuroscience Letters Volume 557, Part B, 17 December 2013, Pages 123–128


Liposomal-formulated curcumin [Lipocurc™] targeting HDAC (Histone Deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson’s disease: implications for epigenetics-based nanotechnology-driven drug platform

Simon Chiu, Kristen J. Terpstra, Yves Bureau, Jirui Hou, Hana Raheb, Zack Cernvosky, Vladimir Badmeav, John Copen, Mariwan Husni, Michael Woodbury-Farina
Journal of Complementary and Integrative Medicine. Volume 10, Issue 1, Pages 75–88, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: 10.1515/jcim-2013-0020, November 2013


A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research

Marco A. S. Baptista, Kuldip D. Dave, Niketa P. Sheth, Shehan N. De Silva, Kirsten M. Carlson, Yasmin N. Aziz, Brian K. Fiske, Todd B. Sherer, Mark A. Frasier
Dis. Model. Mech. November 2013, doi: 10.1242/dmm.011940 vol. 6 no. 6 1316-1324