Pink1 (Park6) knockout rat

Pink1 (Park6) Knockout

Pink1 (Park6) knockout rat

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Research model for Parkinson's disease and stress induced neurological disfunctions.

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  • Description
  • Publications

Pink1 (Park6) knockout rat

Nomenclature: LEH- Pink1 tm1sage

Origin: Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson’s disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.

Characteristic

  • homozygous knockout rats exhibit complete loss of target protein
  • approximately 30% of Pink1 knockout rats display a hindlimb-dragging phenotype at 5 months of age
  • Pink1 knockout rats show increased hindlimb fatigue at 7 weeks of age
  • Pink1 knockout rats show increased number of hindlimb foot slips at 5 and 9 weeks of age as assessed by tapered balance beam
  • preliminary reports have suggested Pink1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age
  • background strain: Long Evans Hooded

Research aplications

  • Parkinson’s disease
  • stress-induced neurological dysfunction

Coat color: White with black cover, exceptional white with brown cover.

Strain code: TGRL4690

Bred in: US

Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats

Jianjun Suna, Evguenia Kouranovac, Xiaoxia Cuic, Robert H. Macha, Jinbin Xu
Neuroscience Letters Volume 557, Part B, 17 December 2013, Pages 123–128


Liposomal-formulated curcumin [Lipocurc™] targeting HDAC (Histone Deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson’s disease: implications for epigenetics-based nanotechnology-driven drug platform

Simon Chiu, Kristen J. Terpstra, Yves Bureau, Jirui Hou, Hana Raheb, Zack Cernvosky, Vladimir Badmeav, John Copen, Mariwan Husni, Michael Woodbury-Farina
Journal of Complementary and Integrative Medicine. Volume 10, Issue 1, Pages 75–88, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: 10.1515/jcim-2013-0020, November 2013


A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research

Marco A. S. Baptista, Kuldip D. Dave, Niketa P. Sheth, Shehan N. De Silva, Kirsten M. Carlson, Yasmin N. Aziz, Brian K. Fiske, Todd B. Sherer, Mark A. Frasier
Dis. Model. Mech. November 2013, doi: 10.1242/dmm.011940 vol. 6 no. 6 1316-1324