PXR knockout rat

PXR knockout rat

Knockout model to study the role of nuclear receptors in the impact of carcinogenic substances, the compounds of xenobiotic metabolism and hepatotoxicity.

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  • Description

PXR knockout rat

Nomenclature: SD- Nr1i2 tm1sage

Genotype: Homozygous

Description: PXR is involved in the induction of cytochrome p4503A (Cyp3a) and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.

Research applications:

  • xenobiotic sensor
  • cytochrome p450 pathways
  • drug metabolism
  • hepatotoxicity
  • cholestasis

Coat color: White, albino.

Strain code:  TGRS4130

Bred in: US

Recommended diet: Purina #5008

Additional information: The activation of nuclear receptors, including the Pregnane X Receptor (PXR) and the Constitutive Androstane Receptor (CAR), is a common Mode of Action (MoA) for chemicals that exhibit non-genotoxic hepatocarcinogenicity in rodents. Conversely, the activation of the human PXR and/or CAR receptors is not believed to result in a carcinogenic response. Therefore, if a compound causes liver tumors in rodents, or if studies demonstrate that the compound is a nuclear receptor agonist, it is critical to unambiguously demonstrate the role of specific nuclear receptors in the rodent response, for example by using PXR or CAR KO rats.

SAGE Labs has partnered with CXR Biosciences to provide mechanistic toxicology services in our PXR and CAR knockout rats. CXR has extensive experience of working with global pharmaceutical, chemical and agrochemical companies to demonstrate the absence of human relevance for nuclear-receptor mediated carcinogenicity.