Trpv1 knockout rat

Trpv1 knockout rat

Trpv1 knockout rat

The model has biallelic TRPV1 gene deletion, which is useful in the study of pain, nociception, analgesia, and thermoregulation.

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  • Description

Trpv1 knockout rat

Nomenclature: SD- Trpv1 tm1sage

Genotype: Homozygous

Description: This model contains a biallelic deletion of the Trpv1 gene, encoding for the transient receptor potential cation channel subfamily V member 1. Capsaicin, the component in chili peppers that makes them hot, is an exogenous ligand for Trpv1. Trpv1 is also activated by heat.

Research applications:

  • pain
  • nociception
  • analgesia
  • thermoregulation
  • cannabinoids


  • homozygous knockout rats exhibit complete loss of Trpv1 protein
  • Trpv1 knockout rats show hyposensitivity to thermal pain via hot plate assay
  • background strain: Sprague-Dawley

Coat color: White, albino.

Strain code: TGRS5530

Bred in: US