Pressure and flowrate studies in large animals
Measurements of arterial pressure and blood flow in large animals allow better understanding of altered organ function. The webinar will cover instrumentation of Millar pressure catheters and Transonic flow probes and consequent measurement of arterial pressure and blood flow in the conscious ovine model. Dr Ramchandra will discuss ovine models of heart failure and hypertension. Finally, he will report on recent data from his lab examining changes in carotid and renal blood flow in an ovine model of hypertension.
Throughout Rohit's career he has been interested in the mechanisms controlling sympathetic nerve activity during normal physiology and during pathophysiology conditions. He undertook his PhD at the Department of Physiology, University of Auckland investigating the role of the sympathetic nervous system and nitric oxide in the control of blood pressure. His interest in the possibility that the differential control of sympathetic nerve activity may be regulated by forebrain areas led him to undertake his postdoctoral studies at the Florey Institute of Neuroscience and Mental Health. Together with his mentor, Professor Clive May, he published numerous papers investigating the reflex control of directly recorded cardiac sympathetic nerve activity in heart failure. He re-located back to Auckland in 2014 where he is running his own lab investigating autonomic control of the circulation in ovine models of hypertension and heart failure.