genOway

Immunodeficient BRGSF mouse model

Code BRG SF mice
Compared to the traditional immunodeficient strains such as NOD-SCID and NSG, the BRGSF mouse represents the most adapted animal model to study and predict human immune responses in vivo.
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Features

Applications

This next generation mouse is a unique preclinical model to study:

  • Vaccine development
  • Efficacy and safety of chimeric antigen receptor (CAR) T cell therapy
  • Myeloid compartment development
  • Patient-derived xenograft (PDX)
  • Human CD34+ hematopoietic stem cell engraftment (see BRGSF-HIS)

Features

  • Highly permissive to patient-derived xenografts (PDXs) and cell line engraftment by virtue of the SIRPαNOD expression
  • Suitable to assess the effects of radiation in vivo due to the absence of the SCID mutation on a BALB/c background
  • A powerful tool for complement-dependent cytotoxicity (CDC) studies because of the presence of a functional murine complement system

Detailed information on genOway website.