ApoE mouse (JAX™); B6.129P2-Apoetm1Unc/J
Nomenclature: B6.129P2-Apoetm1Unc/J
Type: Genetically engineered, Inbred mice
Origin: The Apoetm1Unc mutant strain was developed in the laboratory of Dr. Nobuyo Maeda at The University of North Carolina at Chapel Hill. The 129-derived E14Tg2a ES cell line was used. The plasmid used is designated as pNMC109 and the founder line is T-89 in the primary reference. The strain was produced by backcrossing the Apoetm1Unc mutation 10 times to C57BL/6J mice. Pedigree mice from The Jackson Laboratory were transferred to Charles River Laboratories UK in October 2004.
Mice homozygous for the Apoetm1Unc mutation show a marked increase in total plasma cholesterol levels that are unaffected by age or gender. Fatty streaks in the proximal aorta are found at three months of age. The lesions increase with age and progress to lesions with less lipid but more elongated cells, typical of a more advanced stage of pre-atherosclerotic lesion.
Coat color: Black
Strain code: 622
Ideal for: Cardiovascular research (atherosclerosis, heart abnormalities, hypercholesterolemia, hypertriglyceridemia, vascular defects)
JAX™ Stock No: 002052
More information about the strain:
Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.
JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
Charles River Laboratories is the official distributor of JAX mice in Europe. Click and read more.
Bred in: Italy
Health reports: Using strain nomenclature find the strain at links below
*Photos provided courtesy of Charles River