JAX

NOD rag gamma (NRG) mouse (JAX™), NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

Code NRG

These NRG mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.

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Immunology Oncology, cancer

Features

Nomenclature: NOD.Cg-Rag1^tm1Mom Il2rg^tm1Wjl/SzJ

Type: Immunodeficient, Inbred

Origin: These mice are most commonly called NRG and are extremely immunodeficient. The mice carry two mutations on the NOD/ShiLtJ genetic background; a targeted knockout mutation in recombination activating gene 1 (Rag1) and a complete null allele of the IL2 receptor common gamma chain (IL2rg^null). The Rag1^null mutation renders the mice B and T cell deficient and the IL2rg^null mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells (HSC) and patient-derived xenografts (PDX) at high efficiency. The immunodeficient NRG mice are more resistant to irradiation and genotoxic drugs than mice with a scid mutation in the DNA repair enzyme Prkdc.

Note: Research institutions (non-profit) require a MTA (Material Transfer Agreement), and companies require a license prior to shipping. This includes mice shipped as part of our model evaluation programme. For more information, please see the Terms of Use tab on the NRG mouse page on The Jackson Laboratory website.

See Charles River webpage with resources about immunodeficient models: Immunodeficient Mice and Rats

Coat color: White (albino)

Strain code: 688

Ideal for: Cancer Research, Immunology, Inflammation and Autoimmunity Research, Hematological Research, Internal/Organ Research

JAX™ Stock No: 007799

More information about the strain:

Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.

Charles River Laboratories is the official distributor of JAX mice in Europe. Click and read more.

Bred in: UK

Health reports: Using strain nomenclature find the strain at links below

animals health reports bred in Charles River UK

*Photos provided courtesy of Charles River

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Charles River, JAX Disease and immunodeficient animal models flyer EN

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Strategie minimalizacji wpływu dryfu genetycznego i maksymalizacji powtarzalności wyników w badaniach prowadzonych z wykorzystaniem myszy