db/db mice (JAX™); BKS.Cg-Dock7m+/+Leprdb/J
Nomenclature: BKS.Cg-Dock7m +/+ Leprdb/J
Type: Inbred mice
Origin: Spontaneous mutation on the congenic C57BLKS/J. The diabetic mutation results from a point mutation in the gene of leptin receptor Lepr. Bred. In Charles River since May 2002 under license and breeding standard of The Jackson Laboratory.
db/db mice are used to model phase 1 to 3 of diabetes type II and obesity. Mice that are homozygous for the diabetes spontaneous mutation (Leprdb) demonstrate morbid obesity, chronic hyperglycemia, pancreatic beta cell atrophy and come to be hypoinsulinemic. Affected mice are polyphagic, polydipsic, and polyuric. Obesity begins at three to four weeks of age. The BKS background brings an uncontrolled rise in blood sugar, severe depletion of insulin-producing beta-cells of the pancreatic islets, peripheral neuropathy, myocardial disease and death by ten months. Exogenous insulin results in loss of control of blood glucose levels, while gluconeogenic enzyme activity increases. Metabolic efficiency is increased, while wound healing is postponed.
Coat color: Black
Strain code: 607
Ideal for: Phase I, II, and III type 2 diabetes, obesity research, wound healing
JAX™ Stock No: 000642
More information about the strain:
Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.
JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
Charles River Laboratories is the official distributor of JAX mice in Europe. Click and read more.
Bred in: Italy
Health reports: Using strain nomenclature find the strain at links below
*Photos provided courtesy of Charles River