Precision Dosing for In-Vivo & In-Vitro Studies
With its precisely controlled aerosol, PreciseInhale® offers versatility across various exposure modules. Whether sourced from dry powders, inhalers, or nebulized solutions, the aerosol optimization caters to a diverse array of substrates. Serving as an exposure platform, PreciseInhale® facilitates small-scale inhalation experiments, delivering accurate doses for in vivo animal studies, ex vivo lung experiments, and material deposition for in vitro exposure and dissolution testing.
Benefits
- Accuracy in dose delivered to the lungs
- Full PK test with minimal amounts of substance
- Consistency of aerosol generation across different formulations: from aqueous formulations (solutions or suspensions) to dry powders
- Substance delivered to the deep lungs
- Strong de-aggregation capability: possibility to aerosolize APIs without formulation
- Minimization of gastrointestinal exposure: accurate PK curves
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Gerde P, Nowenwik M, Sjöberg CO, Selg E. Adapting the Aerogen Mesh Nebulizer for Dried Aerosol Exposures Using the PreciseInhale Platform. J Aerosol Med Pulm Drug Deliv. 2020 Apr;33(2):116-126. doi: 10.1089/jamp.2019.1554. Epub 2019 Oct 15. PMID: 31613690; PMCID: PMC7133437.
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