Pressure Myograph System - 114P
The Pressure Myograph System - 114P is used to measure small arteries, veins, and other vessels physiological function and properties. It allows studying pharmacological effects of drugs and other vasoactive compounds on small isolated vessels under near-physiological conditions. A small, intact segment of an artery or vein is mounted onto two small glass cannulas and pressurized to a suitable transmural pressure. The near-physiological condition permits the investigation of myogenic responses, flow-mediated dilation, and pharmacological agent testing, either to the superfusate or luminal solution.
A built-in heating system maintains the chamber temperature, eliminating the need for continuous and often costly superfusion. The chamber cover includes ports for superfusion, rapid draining and filling, cumulative addition of drugs, and oxygenation. To facilitate cleaning, the chamber is made of acid-resistant stainless steel.
The state-of-the-art Pressure Myograph software MyoVIEW will collect data such as vessel wall thickness, changes in vessel and lumen diameter, intravascular pressure, and a host of other calculated parameters, such as shear stress and vascular resistance, setting pressure or perfusion myography apart from standard organ bath techniques.
As an option, the FlowMeter - 162FM can be added to the system to measure flow between 15-4000μl/min.
Myograph Chamber
- Constant transmural pressure or luminal flow situation
- Visualization of vessel through optical base window
- Longitudinal force measurements
- Vessel diameter >30µm and <10mm length
- In-line pressure transducers
- XYZ alingment of pressurized vessel
- Acid resistant stainless steel chamber
Interface Unit
- Intregreted buffer resevoir (heated)
- Direct data streaming
- Integrated heat control
- Intregreted force and pressure calibration procedure
- Intuitive touch-screen menus
- Compact design / small footprint
Diameter Tracking Software
- Live detection
- Multiple zones for edge detection
- Multiple scanlines for accurate measurements
- Event markers and tracking
- Real-time calculations of diameter, wall thickness, cross-sectional area, flow, vascualr resistance, shear stress and more