Analgesy-meter the 1st and original Randall-Selitto paw-pressure test
Measures the force on a rat or mouse paw according to the Randall-Selitto paw-pressure test, it enables rapid and precise screening of analgesic drugs for anti-nociceptive studies, in healthy or inflamed limbs. The device applies a steady increasing force, starting and stopping using the foot pedal. No calibration required. Digital model with force sensors and electronic unit is also available.
Exerts a steadily increasing force with easy start and stop. No calibration required. Design maximises care for animals. Model with digital reading available.
Features
- Same instrument, three different force ranges
- No calibration needed
- Classic method since the 1960s
- NEW model with digital reading
Applied force
- 37215 from 0 to 250, 500, 750grams (with extra weights)
- 37216 from 0 to 125, 250, 375grams (with extra weights)
- Simple and reliable
- More than 1000 papers published!
- Upgrade kit for old UB Analgesy-Meters available
Applications of analgesy meter from Ugo Basile
The Basile Analgesy-Meter has been designed to perform rapid precise screening of an-algesic drugs on the normal and inflamed rat paw, according to the Randall-Selitto test.
The instrument is basically a device which exerts a force increasing at a constant rate (a certain number of grams per second). This force is continuously monitored by a pointer moving along a linear scale.
The force is applied to the animal’s paw, which is placed on a small plinth under a cone-shaped pusher with a rounded tip. The plinth is made of TEFLON, which is biologically inert and has a very low friction coefficient. Thus, if the animal suddenly withdraws its paw, it slips out easily without being injured.
The operator depresses a pedal-switch to start the mechanism which exerts the force.
When the rat struggles, the operator releases the pedal and reads off the scale the force at which the animal felt pain.
- 37215-100 Upgrade kit for analgesy meter, for automatic response recroding, including electronic unit with software and transducer
- Exchange factor directly activated by cAMP–PKCε signalling mediates chronic morphine‐induced expression of purine P2X3 receptor in rat dorsal root ganglia W Wang, X Ma, L Luo, M Huang, J Dong, X Zhang… - British Journal of Pharmacology (Rats)
- Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic … K Hayashida, M Kimuram, JC Eisenach - Neuroscience Letters, 2018 (Rats)
- Evaluation of Antipyretic and Analgesic Effects of Aqueous Extract of Leaves of Vernonia Amygdalina Del.(Asteraceae) RDG Elion Itou, AW Etou Ossibi, GF Nsonde Ntandou, Bioequialence & Bioavailability J., 2018 (Mice, Rats)
- Benzimidazole derivatives and use thereof L Tafesse, J Yao, X Zhou - US Patent App. 15/820,103, 2018 (Mice)
- Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors Á Montilla-García, G Perazzoli, MÁ Tejada… - Neuropharmacology, 2018 (Mice, knockout)
- Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic … K Hayashida, M Kimuram, JC Eisenach - Neuroscience Letters, 2018 (Rats)
- Evaluation of Antipyretic and Analgesic Effects of Aqueous Extract of Leaves of Vernonia Amygdalina Del.(Asteraceae) RDG Elion Itou, AW Etou Ossibi, GF Nsonde Ntandou, Bioequialence & Bioavailability J., 2018 (Mice, Rats)
- Benzimidazole derivatives and use thereof L Tafesse, J Yao, X Zhou - US Patent App. 15/820,103, 2018 (Mice)
- Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic … K Hayashida, M Kimuram, JC Eisenach - Neuroscience Letters, 2018
Method Paper
- L.O. Randall and J.J. Selitto: “A Method for Measurement of Analgesic Activity on Inflamed Tissue” Arch. Int. Pharmacodyn. CXI, No. 4: 409-419, 1957