Swiss Nude mice, Crl:NU(Ico)-Foxn1nu
Nomenclature: Crl:NU(Ico)-Foxn1nu
Type: Outbred, Immunodeficient
Origin: The mutation occurred in 1962 in a colony of albino outbred mice maintained at the Ruchill Hospital in Glasgow. In 1966, Flanagan gave the first detailed description of this mutant. However, it was not until 1968 that it was first noticed that the thymus was missing. These nude mice originate from the Swiss strain. In 1974, the Gustave Roussy Institute (Villejuif, France) obtained the mice from Dr. Carl Hansen's department at NIH in Bethesda, MD, USA. The first pairs were introduced to Charles River France in 1976.
See Charles River webpage with resources about immunodeficient models: Immunodeficient Mice and Rats
Coat color: Hairless, albino background
Strain code: 620
Ideal for: Tumor biology and xenograft research
Bred in: France
Health reports: Using strain nomenclature find the strain at links below
Learn more about immudeficient models bred by Charles River.
*Photos provided courtesy of Charles River
Piedrahita JA; Zhang SH; Hagaman JR; Oliver PM; Maeda N. 1992.
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.
Proc Natl Acad Sci U S A 89(10):4471-5 PubMed: 1584779 MGI: J:1050