K18-hACE2 mouse (JAX™)
Nomenclature: B6.Cg-Tg(K18-ACE2)2Prlmn/J
Type: Genetically engineered
Origin: K18-hACE2 transgenic mice express human ACE2, the receptor used by the severe acute respiratory syndrome coronavirus (SARS-CoV) to gain entry to cells. Expression is driven in epithelia by a human keratin 18 (KRT18) promoter. Most importantly, expression is observed in airway epithelial cells where infections typically begin. This model of lethal infection with SARS-CoV mimics the human disease and should be useful for studies of pathogenesis and for the development of antiviral therapies for SARS. Recent research indicates that this line may also be useful in studies related to the study of 2019 novel coronavirus (SARS-CoV-2) pathogenesis and the COVID-19 outbreak.
Coat color: Black
Strain code: 704
JAX™ stock no.: 034860
More information about the strain:
Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.
JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
Charles River Laboratories is the official distributor of JAX mice in Europe. Click and read more.
Ideal for: Internal organ research, virology, research tools, developmental biology, immunology, inflammation, and autoimmunity research.
Bred in: US
Health reports: Find health monitoring on JAX strain website
*Photos provided courtesy of Charles River