Charles River Laboratories

LVG Golden Syrian Hamster, Crl:LVG(SYR)

Code HAMSCFE100110
One of the best animal model for COVID-19 reserach with many others applications in behavioral studies, toxicity, infectious diseases and carcinogenicity.
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Nomenclature: Crl:LVG(SYR)

Type: Outbred

Origin: The Golden Syrian Hamster is applicable for studies relating to SARS-CoV-2 due to its high levels of sequence homology with human ACE2 receptors and strong viral titers within 48 hours of inoculation. The model exhibits maximum clinical signs such as high lung viral load, cytokine activation, spleen and lymphoid atrophy, and can develop serum antibodies. Three members of a litter captured in Syria in 1930 were retained in captivity. It is the progeny of these golden hamsters that were first imported to the United States in 1938. Descended from two original colonies acquired by Lakeview in 1949 and 1951. Closed outbred colony since 1951. To Charles River in 1969.

Coat color: Medium tan

Strain codes: 049

Ideal for:SARS-CoV-2, carcinogenicity, behavioral studies, toxicity, infectious disease, general multipurpose model

  • LVG Golden Syrian Hamster: Relevancy and application in COVID-19 research
  • Learn more about Animal Model Evaluation Program to assess the quality and compatibility of our animal models before making a commitment.

    How are Golden Syrian Hamsters used in SARS-CoV2 research?

    The LVG Golden Syrian Hamster supports growth of SARS-CoV-2 with robust viral titers within 48 hours of inoculation. Ease of handling, natural infection, and efficient transmission make this an ideal research model for your COVID-19 studies. Applications:

    • Investigation of pathogenesis and transmission of SARS-CoV-2
    • Vaccine and treatment generation against SARS-CoV-2

    What are some features of the LVG Golden Syrian Hamster?

    • High level of sequence homology with human ACE2 receptor
    • Consistent infection with SARS-CoV-2
    • Maximum clinical signs such as alveolar damage, high lung viral load, cytokine activation, spleen and lymphoid atrophy, and development of serum antibodies

    Bred in: US

    Health reports: Using strain nomenclature find the strain at link below

    *Photos provided courtesy of Charles River