NMRI Nude mouse, Crl:NMRI-Foxn1nu
Nomenclature: Crl:NMRI-Foxn1nu
Type: Outbred, Immunodeficient
Origin: The first nude mouse appeared at the Virus Laboratory, Ruchill Hospital in Glasgow in 1962 in Dr. N.R. Grist's laboratory. Dr. Grist sent the mutation to Edinburgh for investigation. The mutation arose in a closed but not deliberately inbred albino stock. The genetics of the mutant nude mouse was studied at the institute of Animal Genetics Edinburgh. Absence of thymus was described by Pantelouris (1968). In December 1968, Dr. Rygaard obtained two heterozygous pairs (nu/+) from the Institute for Animal Genetics in Edinburgh, Scotland. Due to poor viability and fertility of the nude mice obtained from Glasgow, Dr. Rygaard decided to transfer the gene to another genetic background. He chose the NMRI outbred strain as the background and soon had a very productive breeding system.
See Charles River webpage with resources about immunodeficient models: Immunodeficient Mice and Rats
Coat color: Hairless, albino background
Strain code: 639
Ideal for: Oncology
Bred in: Germany
Health reports: Using strain nomenclature find the strain at links below
Learn more about immudeficient models bred by Charles River.
*Photos provided courtesy of Charles River