Charles River Laboratories

OT I Mouse; C57BL/6-Tg(TcraTcrb)1100Mjb/Crl

Code 24981022-040

OT-I mice are often used to study CD8+ T cell response to antigen, positive selection, and in any research requiring CD8+ T cells of defined specificity.

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Immunology Inflammation

Features

Nomenclature: C57BL/6-Tg(TcraTcrb)1100Mjb/Crl

Type: Genetically Engineered, Immunodeficient

Origin: From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.

Coat color: Black

Strain code: 642

Ideal for: Immunology, Inflammation and Autoimmunity Research

Bred in: France

Health reports: Using strain nomenclature find the strain at links below

animals health reports bred in Charles River France

*Photos provided courtesy of Charles River