Charles River Laboratories

OT II Mouse; C57BL/6-Tg(TcraTcrb)425Cbn/Crl

Code 24981046-068

Transgenic OT-II mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, and central and peripheral T cell tolerance and induction.

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Immunology Inflammation

Features

Nomenclature: C57BL/6-Tg(TcraTcrb)425Cbn/Crl

Type: Genetically Engineered, Immunodeficient

Origin: From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002. These homozygous transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand.

Coat color: Black

Strain code: 643

Ideal for: T cell biology research (e.g., TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction)

Bred in: France

Health reports: Using strain nomenclature find the strain at links below

animals health reports bred in Charles River France

*Photos provided courtesy of Charles River