PGP mouse, Crl:CF1-Abcb1amds
Nomenclature: Crl:CF1-Abcb1amds
Type: Outbred, Cryopreserved
Origin: In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), that were developed in conjunction with Merck by Charles River Genetically Engineered Models and Services in Wilmington, MA.
Coat color: White (albino)
Strain code: This model is cryopreserved.
Ideal for: PGP-deficient blood brain barrier model, CNS, transport/excretion involving mds (multiple drug sensitive) for neurobiology and chemotherapy, toxicology, teratology, altered intestinal intraepithelial lymphocyte development
Bred in: US
Health reports: The PGP mouse model is cryopreserved.
*Photos provided courtesy of Charles River