Sentry SPP™ Mouse Sealed Positive Pressure Cage

Sentry SPP™ Mouse Sealed Positive Pressure Cage – Sealed Positive-Pressure IVC Cage for Germ-Free and Gnotobiotic Mice

The Sentry SPP™ Mouse is a sealed, positive-pressure (SPP) individually ventilated cage that provides the germ-controlled environment traditionally found only in isolators. It is designed for research involving axenic (germ-free) or gnotobiotic mice (with a limited, defined microbiota) and combines the secure, positive-pressure protection of isolators with the ease and flexibility of an Allentown IVC. Certified cage-level HEPA supply filtration keeps the microenvironment clean, and the gasketed cage remains sealed when it is removed from the rack.

Watering is provided via a water bottle (Cat. no. 228215 is designed for bottle watering only).

Key Features

• Patented four-point seal (US Patent 6,308,660): when a cage is removed, both the cage and the rack remain sealed from the room
• Standard certified cage-level HEPA supply filtration and cage-level exhaust filtration; optional certified cage-level HEPA exhaust filtration
• Gasketed cage lid maintains the sealed microenvironment when the cage is removed from the rack
• SmartDock™ prevents incorrect cage docking
• Ergonomic cage locks provide consistent pressure along the entire cage perimeter; the locks flip up for tunnel washing
• Clear polysulfone cage and flip-up cardholders for easy observation
• Animal welfare checks without fully removing the cage from the rack
• Compact nesting and stacking for efficient autoclaving
• At least 10 hours of rack battery backup, with blower redundancy, wireless monitoring, and alarms

How to Complete the Sentry SPP Mouse Cage Set

The Sentry SPP™ Mouse Sealed Positive Pressure Cage is supplied as a complete cage with the following components:

1. Sentry SPP Mouse cage assembly (cage bottom)

2. Top: Standard Filter Top Assembly with a gasket and ergonomic cage locks

3. Choose one of three wire bar lids and feeders: Dual Pocket Wire Bar Lid (food capacity: 454 g), Full Pocket Wire Bar Lid (food capacity: 426 g), or Hydropac®-compatible Plastic Feeder Tray (PFT) with stainless steel grate (food capacity: 426 g)

4. Choose a water bottle: 250 mL or 430 mL

5. Choose a cardholder: vertical or horizontal (each for 76 × 102 mm or 76 × 127 mm cage cards)

6. Filters: Certified Intra-Cage HEPA Filter (Supply) – standard; Intra-Cage Extract Filter with Extract Filter Housing – standard; Certified Intra-Cage HEPA Filter (Exhaust) – optional

Housing Capacity According to Directive 2010/63/EU

Maximum number of animals per cage, based on the minimum floor area per animal set out in Directive 2010/63/EU:

• Up to 8 mice weighing 20 g or less
• Up to 7 mice weighing over 20 g and up to 25 g
• Up to 6 mice weighing over 25 g and up to 30 g
• Up to 5 mice weighing over 30 g

Applications of the Sentry SPP™ Mouse Cage

• Housing of axenic (germ-free) and gnotobiotic mice as an alternative to isolators
• Microbiome research with defined microbiota
• Immunocompromised mouse models requiring a highly protected microenvironment
• Transport and temporary housing in the Sentry SPP Animal Transfer Unit